Standardization and harmonization of MRI protocols


1.Multimodel Harmonized MRI Imaging Protocol (HARP)
2.HARP Seqence Protocol
3.HARP Protocol Download

1.Multimodel Harmonized MRI Imaging Protocol  (HARP)

HARP is a protocol for high-precision and high-sensitivity imaging of brain structures and functions using multimodel MRI equipment. It was also able to improve the ability to diagnose mental and neurological disorders, and was built by the BMB Project. HARP has been calibrated to run within a clinically practical time frame (within 22 to 65 minutes) and is a high-quality, high-resolution, standardized protocol.
 
HARP takes a high spatial resolution structural image (0.8 mm) (approximately 12 minutes) and two sets of functional MRI images in opposite phase directions (approximately 10 minutes in total). In addition, as optional imaging, functional MRI imaging for approximately 20 minutes, diffusion-weighted imaging for approximately 7 to 10 minutes, 3D arterial spin labeling imaging for approximately 3 minutes (Prisma, Skyra, Verio only), quantitative magnetic field inhomogeneity imaging for 5 minutes (Prisma, Skyra only), and fMRI imaging for 4 minutes for performing 2 types of tasks (EMOTION, CARIT) will be carried out.
 
The equipment and performance requirements for the MRI system to execute HARP are as follows.
1) The static magnetic field strength is 3 tesla.
2) A multi-array head coil with 32 channels or more of radiofrequency reception coils for the head is installed.
3) A multiband EPI sequence provided by the University of Minnesota (Center for Magnetic Resonance Research) or a sequence with equivalent capabilities must be implemented.
 

2.HARP sequence protocol

Structure image   T1W (3D MPRAGE)
Scanner (System version) Prisma (VE11C) Skyra (VE11C) Verio (VD13A) Verio (VB17A) Trio (VB19A)
TR/TE/TI [msec]  2500/2.18/1000
FOV(SI×AP×RL) [mm] 256×240×179.2
Matrix size  320×300×224
Resolution [mm] 0.8×0.8×0.8
Scan time [min:sec]  5:22
Bandwidth [Hz/Px]  220 210
Orientation sagittal (PE dir. : A >> P)
Flip angle [deg]  8
Acceleration Phase partial Fourier: 6/8, GRAPPA (factor:2, ref. line:32) 
Echo spacing [msec]  7.9 7.8
Filter  Distortion Corr OFF, Prescan Normalize ON
Sampling Spacing [μsec]  7.1
Slice oversampling [%]  7.1
Fat Sat  Water excit. fast

T2W (3D T2-SPACE)
Scanner (System version) Prisma (VE11C) Skyra (VE11C) Verio (VD13A) Verio (VB17A) Trio (VB19A)
TR/TE [msec] 3200/564 3200/565 3200/564 3200/562
FOV(SI×AP×RL) [mm] 256×240×179.2
Matrix size  320×300×224
Resolution [mm] 0.8×0.8×0.8
Scan time [min:sec] 5:31 5:22 6:26
Bandwidth [Hz/Px] 744 679 781
Orientation sagittal (PE dir. : A >> P)
Turbo factor 314 326 167 (Slice turbo factor 2)
Acceleration GRAPPA (factor:2, ref.line:32)
Echo spacing [msec] 3.86 3.72 3.48
Filter Distortion Corr OFF, Prescan Normalize ON, Image Filter (Sharp: Edge Enhanvement 3 & Smoothing 3)
Sampling Spacing [μsec] 2.1 2.3 2.1
Slice oversampling [%]  7.1
Excitation Variable flip angles (Flip angle mode: T2 var)

Function image   fMRI (BOLD)
Scanner (System version) Prisma (VE11C) Skyra (VE11C) Verio (VD13A) Verio (VB17A) Trio (VB19A)
TR/TE [msec] 800/34.4
FOV(SI×AP×RL) [mm] 206×206×144
Matrix size/Slices 86×86/60
Resolution [mm] 2.4×2.4×2.4
Scan time [min:sec]  5:08
Bandwidth [Hz/Px] 2076 2326
Orientation Transverse (PE dir. : swapped alternatively btw A >> P & P >> A)
Flip angle [deg] 52
Acceleration Partial Fourier: OFF, Multi-band (factor:6)
Echo spacing [msec] 0.63 0.57
Filter Prescan Normalize ON

Spin echo static magnetic field imaging   fMRI (Spin-echo fieldmap)
Scanner (System version) Prisma (VE11C) Skyra (VE11C) Verio (VD13A) Verio (VB17A) Trio (VB19A)
TR/TE [msec] 6100/60
FOV(SI×AP×RL) [mm] 206×206×144
Matrix size/Slices 86×86/60
Resolution [mm] 2.4×2.4×2.4
Scan time [min:sec] 0:06
Bandwidth [Hz/Px] 2076 2154 2326
Orientation Transverse (PE dir. : swapped alternatively btw A >> P & P >> A)
Flip angle [deg] 90/180
Acceleration Phase Partial Fourier OFF
Echo spacing [msec] 0.63 0.57
Filter Prescan Normalize ON

Diffusion weighted image   DWI (Spin-echo EPI)
Scanner (System version) Prisma (VE11C) Skyra (VE11C) Verio (VD13A) Verio (VB17A) Trio (VB19A)
TR/TE [msec] 3600/79.0 3600/89.0 3600/94.0
FOV(SI×AP×RL) [mm] 204×204×144
Matrix size 120×120×84
Resolution [mm] 1.7×1.7×1.7
Scan time [min:sec] (A→P) 3:29 4:50
Scan time [min:sec] (P→A) 3:32 4:54
Bandwidth [Hz/Px] 1984 1544 1436 1736
Orientation Transverse (PE dir. : swapped alternatively btw A >> P & P >> A)
Flip angle [deg] 90/180
Acceleration Partial Fourier: 6/8, Multi-band [factor: 3] Partial Fourier: 6/8, GRAPPA (ref line 36), Multi-band [factor: 3]
Echo spacing [msec] 0.62 0.74 0.78 0.7
Filter Prescan Normalize ON
b-values [s/mm2] 0/700/2000
Diffusion direction (A→P) 5/16/32 7/20/40
Diffusion direction (P→A) 6/16/32 8/20/40
Diffusion scheme Monopolar


3.HARP Protocol Download

All the parameters of HARP are available in PDF file and/or Siemens installation format (.exar1 or edx). Supports for other vendors, scanner types, versions are planned but not yet scheduled.  Please contact us if your have any requests and questions.
Device System Details file Installation file
Prisma VE11C HARP_Prisma_VE11C_20190617.pdf HARP_Prisma_VE11C_20190617.exar1
Skyra VE11C HARP_Skyra_VE11C_20190617.pdf HARP_Skyra_VE11C_20190617.exar1
VE11E HARP_Skyra_VE11E.pdf HARP_Skyra_VE11E.exar1
Verio VB17A HARP_Verio_VB17A_20190617.pdf HARP_Verio_VB17A_20190617.edx
VD13A HARP_Verio_VD13A_20190617.pdf HARP_Verio_VD13A_20190617.edx
Trio VB19A HARP_Trio_VB19A_20190617.pdf HARP_Trio_VB19A_20190617.edx